Membrane Remodeling: ESCRT-III Filaments as Molecular Garrotes

John McCullough; Wesley I Sundquist

doi:10.1016/j.cub.2020.09.086

Membrane Remodeling: ESCRT-III Filaments as Molecular Garrotes

Curr Biol. 2020 Dec 7;30(23):R1425-R1428. doi: 10.1016/j.cub.2020.09.086.

Authors

John McCullough¹, Wesley I Sundquist²

Affiliations

¹ Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
² Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: wes@biochem.utah.edu.

PMID: 33290710
DOI: 10.1016/j.cub.2020.09.086

Abstract

New reconstitution, biochemical and structural studies are revealing how the core machinery of the ESCRT pathway constricts membranes to promote fission. Equally exciting is the discovery and characterization of conserved ESCRT-like machinery across all three domains of life.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cytoskeleton*
Endosomal Sorting Complexes Required for Transport* / genetics
Polymerization

Substances

Endosomal Sorting Complexes Required for Transport

Grants and funding

R37 AI051174/AI/NIAID NIH HHS/United States