Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses

Int J Mol Sci. 2020 Dec 5;21(23):9289. doi: 10.3390/ijms21239289.


Medical research is changing into direction of precision therapy, thus, sophisticated preclinical models are urgently needed. In human pathogenic virus research, the major technical hurdle is not only to translate discoveries from animals to treatments of humans, but also to overcome the problem of interspecies differences with regard to productive infections and comparable disease development. Transgenic mice provide a basis for research of disease pathogenesis after infection with human-specific viruses. Today, humanized mice can be found at the very heart of this forefront of medical research allowing for recapitulation of disease pathogenesis and drug mechanisms in humans. This review discusses progress in the development and use of transgenic mice for the study of virus-induced human diseases towards identification of new drug innovations to treat and control human pathogenic infectious diseases.

Keywords: human pathogenic viruses; humanized mouse models; transgenic mice.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Gene Expression Regulation, Viral
  • Host-Pathogen Interactions
  • Humans
  • Immune System
  • Mice, Transgenic*
  • Organ Specificity
  • Receptors, Cell Surface / metabolism
  • Viral Tropism
  • Virus Diseases / diagnosis
  • Virus Diseases / etiology*
  • Virus Diseases / therapy
  • Virus Replication


  • Receptors, Cell Surface