NOD-like receptor-mediated plant immunity: from structure to cell death

Nat Rev Immunol. 2021 May;21(5):305-318. doi: 10.1038/s41577-020-00473-z. Epub 2020 Dec 8.


Animal and plant immune systems use intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) to detect pathogens, resulting in the activation of immune responses that are often associated with localized host cell death. Whereas vertebrate NLRs detect evolutionarily conserved molecular patterns and have undergone comparatively little copy number expansion, plant NLRs detect virulence factors that have often diversified in plant pathogen populations, and thus plant NLRs have been subject to parallel diversification. Plant NLRs sense the presence of virulence factors with enzymatic virulence activity often indirectly through their modification of host target proteins. By contrast, phytopathogenic virulence factors without enzymatic activity are usually recognized by NLRs directly by their structure. Structural and biochemical analyses have shown that both indirect and direct recognition of plant pathogens trigger the oligomerization of plant NLRs into active complexes. Assembly into three-layered ring-like structures has emerged as a common principle of NLR activation in plants and animals, but with distinct amino-terminal domains initiating different signalling pathways. Collectively, these analyses point to host cell membranes as a convergence point for activated plant NLRs and the disruption of cellular ion homeostasis as a possible major factor in NLR-triggered cell death signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Cell Death / immunology*
  • Host Microbial Interactions / immunology
  • Models, Immunological
  • Models, Molecular
  • NLR Proteins / chemistry
  • NLR Proteins / immunology*
  • Plant Cells / immunology
  • Plant Immunity*
  • Plant Proteins / chemistry
  • Plant Proteins / immunology*
  • Plants / microbiology
  • Signal Transduction / immunology


  • NLR Proteins
  • Plant Proteins