Quality of life and factors affecting it in adult cancer patients undergoing cancer chemotherapy in a tertiary care hospital

Cancer Rep (Hoboken). 2021 Apr;4(2):e1312. doi: 10.1002/cnr2.1312. Epub 2020 Dec 9.

Abstract

Background: Cancer is the second most common cause of deaths worldwide. Likewise, in India, it is a major health problem, and disease burden is escalating every year. Cancer chemotherapy produces unfavorable effects on the well-being of an individual. Since the past few years, quality of life (QoL) is considered as the main goal of cancer treatment in the survival of a patient.

Aim: This current study aimed to assess the QoL and factors affecting it in adult cancer patients undergoing chemotherapy treatment.

Methods and results: An analytical, cross-sectional study was conducted to achieve the objectives, employing the consecutive sampling method. A total of 120 adult (>19 years) patients were recruited from daycare chemotherapy unit of a tertiary care hospital. The data were collected using patient record form and Functional Assessment of Cancer Therapy-General (FACT-G), a quality of life (QoL) questionnaire. The overall mean score of quality of life (QoL) was 61.933 ± 5.85502. The domains of functional well-being and emotional well-being were most negatively affected after cancer chemotherapy. Education (illiteracy) and occupation (unemployment) were negatively associated with overall quality of life (QoL) of cancer patients on chemotherapy. Adverse drug reactions due to cancer chemotherapy negatively affect the quality of life (QoL) of cancer patients. Education (illiteracy) affects social well-being domain of cancer patients. Working in the government/private sector has a positive impact on functional well-being domain of quality of life (QoL).

Conclusion: The study findings suggest an overall low quality of life (QoL) among adult cancer patients undergoing chemotherapy at our setup. It has been identified as a stressful therapy, also affecting both psychological and physical well-being. Poor infrastructure, illiteracy, poverty, and lack of proper treatment facilities at most centres often lead to poor survival outcomes and hence focus has always been on achieving quantity of life rather than quality of life (QoL). This is further complicated due to nonavailability of validated tools in local vernacular, apathy of the treating physicians in the context of QoL aspects and social and cultural factors that are unique to this society. Psycho-oncology needs to become an integral entity of comprehensive cancer care.

Keywords: FACT-G; cancer chemotherapy; domains; quality of life (QoL); tertiary care hospital.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Cross-Sectional Studies
  • Educational Status
  • Female
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Neoplasms / complications
  • Neoplasms / drug therapy*
  • Neoplasms / mortality
  • Neoplasms / psychology
  • Quality of Life*
  • Surveys and Questionnaires / statistics & numerical data
  • Survival Analysis
  • Tertiary Care Centers / statistics & numerical data
  • Young Adult

Substances

  • Antineoplastic Agents