Evaluation of the relationship of serum vitamin D levels in COVID-19 patients with clinical course and prognosis

Tuberk Toraks. 2020 Sep;68(3):227-235. doi: 10.5578/tt.70027.


Introduction: SARS-CoV-2 (COVID-19), which emerged in Wuhan, China in December 2019, infected more than six million people in a short time. In COVID-19, the relationship of many laboratory parameters to morbidity and mortality has been defined. In our study, we aimed to determine the relationship of serum vitamin D level to clinical course and prognosis.

Materials and methods: This study included 108 patients; 88 patients who stayed in Ataturk University and Erzurum City Hospital between March 24, 2020 and May 15, 2020, who were identified as COVID-19 by real-time PCR method from the nasopharyngeal swab and 20 asymptomatic voluntary medical personnel who tested negative for real-time PCR after routine check-up in our hospital.

Result: In statistical analysis conducted between healthy control group and vitamin D levels of patients admitted due to COVID-19, it was observed that patients infected with COVID-19 had a lower level (p= 0.004). In 20 patients developing MAS, a lower level of vitamin D was observed (p= 0.004) compared to 68 patients who did not develop. In the comparison of vitamin D levels of the patients (n= 8) who developed exitus in their follow up due to COVID-19, it was observed that vitamin D levels were statistically significantly lower compared to the living (p= 0.009).

Conclusions: Due to COVID-19, pandemic, long-running quarantines caused insufficient use of sunlight and worsening of vitamin D deficiency. We wanted to draw attention again with our study to vitamin D which can be responsible for the heavy clinical course of COVID-19 and whose replacement is easy to apply.

MeSH terms

  • COVID-19 / blood*
  • COVID-19 / diagnosis*
  • COVID-19 Testing
  • Female
  • Humans
  • Male
  • Prognosis
  • Quarantine / statistics & numerical data*
  • Real-Time Polymerase Chain Reaction
  • Risk Factors
  • SARS-CoV-2
  • Vitamin D / blood*
  • Vitamin D Deficiency / diagnosis*


  • Vitamin D