Comparison of ultrasound-guided platelet-rich plasma injection and conventional physical therapy for management of adhesive capsulitis: a randomized trial

J Int Med Res. 2020 Dec;48(12):300060520976032. doi: 10.1177/0300060520976032.


Objective: We evaluated the effect of ultrasound (US)-guided injection of platelet-rich plasma (PRP) into the shoulder joint in patients with adhesive capsulitis (AC) and compared its effect with that of conventional physiotherapy (CPT).

Methods: Sixty-four subjects with AC were included and randomly allocated into two groups, as follows: PRP (n=32; intra-articular [IA] PRP [4 mL] was injected); and CPT (n=32; short wave diathermy and exercise therapy were performed at three sessions/week for 6 weeks). Treatment outcomes evaluated therapeutic effectiveness before and at 1, 3, and 6 weeks after PRP injection and CPT initiation.

Results: Subjects in both groups showed a significant decrease in the visual analogue scale score for pain and shoulder and hand scores, and they a significant increase in shoulder passive range of motion at all evaluation time points. There was no significant difference in the measured outcomes between the two groups. However, there was less acetaminophen consumption after IA PRP injection compared with that after CPT.

Conclusions: IA PRP injection is a useful option for treating patients with AC, particularly those who have low therapeutic compliance for exercise therapy or have contraindications for corticosteroid injection or oral pain reduction medication.

Keywords: Shoulder; articular; pain; pain management; platelet-rich plasma; range of motion; ultrasonography.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Bursitis* / diagnostic imaging
  • Bursitis* / therapy
  • Humans
  • Physical Therapy Modalities
  • Platelet-Rich Plasma*
  • Range of Motion, Articular
  • Treatment Outcome
  • Ultrasonography, Interventional