Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial

Nutrients. 2020 Dec 7;12(12):3757. doi: 10.3390/nu12123757.


A reduction in estrogen levels in the perimenopausal and postmenopausal periods causes various symptoms in women, such as hot flushes, sweats, depression, anxiety, and insomnia. Chlorogenic acids (CGAs), which are phenolic compounds widely present in plants such as coffee beans, have various physiological functions. However, the effects of CGAs on menopausal symptoms are unknown. To examine the effects of CGAs on menopausal symptoms, especially hot flushes, a randomized, placebo-controlled, double-blind, parallel-group trial was conducted in healthy women. Eighty-two subjects were randomized and assigned to receive CGAs (270 mg) tablets or the placebo for 4 weeks. After 4 weeks of intake, the number of hot flushes, the severity of hot flushes during sleep, and the severity of daytime sweats decreased significantly in the CGA group compared to the placebo group. The modified Kupperman index for menopausal symptoms decreased significantly after 2 weeks in the CGA group compared to the placebo group. Adverse effects caused by CGAs were not observed. The results show that continuous intake of CGAs resulted in improvements in menopausal symptoms, especially hot flushes, in healthy women.

Keywords: chlorogenic acid; hot flushes; menopausal symptoms.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Chlorogenic Acid / administration & dosage*
  • Coffee / chemistry*
  • Double-Blind Method
  • Female
  • Healthy Volunteers
  • Hot Flashes / drug therapy*
  • Humans
  • Menopause / drug effects*
  • Middle Aged
  • Plant Extracts / administration & dosage*
  • Sleep / drug effects
  • Treatment Outcome


  • Coffee
  • Plant Extracts
  • Chlorogenic Acid