Cutaneous acantholytic dyskeratotic acanthoma accompanying syringofibroadenomatous hyperplasia with proliferation of mature sebocytes: A case report

J Cutan Pathol. 2021 Mar;48(3):451-454. doi: 10.1111/cup.13933. Epub 2020 Dec 22.


Acantholytic dyskeratotic acanthoma is a rare variant of epidermal acanthoma. It has a flat, plaque-like structure and is characterized microscopically by acantholysis and dyskeratosis. Eccrine syringofibroadenomatous hyperplasia is benign and likely reactive. It has recently been considered as a hyperplastic process affecting the eccrine ducts rather than the neoplasm because of its pathological heterogeneity and wide clinical associations. In this article, we present the case of 97-year-old Japanese women with a 10-mm wide, painful acantholytic dyskeratotic acanthoma accompanied by syringofibroadenomatous hyperplasia in the right femoral region. Although syringofibroadenomatous hyperplasia is known to occur as a reactive process with various dermatoses and cutaneous tumors, to date, there have been no reports of cases of acantholytic dyskeratotic acanthoma accompanying syringofibroadenomatous hyperplasia. Moreover, this case also includes the unusual finding of an increase in the mature sebocytes in the area of the syringofibroadenomatous hyperplasia.

Keywords: acantholytic dyskeratotic acanthoma; cutaneous; sebocyte; syringofibroadenomatous hyperplasia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acantholysis / diagnosis
  • Acantholysis / pathology*
  • Acanthoma / diagnosis*
  • Acanthoma / surgery
  • Acanthoma / ultrastructure
  • Aged, 80 and over
  • Asian People / ethnology
  • Cell Proliferation
  • Diagnosis, Differential
  • Epidermis / pathology*
  • Female
  • Humans
  • Hyperplasia / diagnosis
  • Hyperplasia / pathology
  • Middle Aged
  • Pain / diagnosis
  • Pain / etiology
  • Poroma / diagnosis*
  • Poroma / pathology
  • Skin / pathology
  • Skin Neoplasms / pathology*
  • Sweat Gland Neoplasms / pathology*