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Comparative Study
. 2020 Dec 1;3(12):e2028337.
doi: 10.1001/jamanetworkopen.2020.28337.

Assessment of Tau Tangles and Amyloid-β Plaques Among Super Agers Using PET Imaging

Merle C Hoenig  1   2 , Niclas Willscheid  2 , Gérard N Bischof  2 , Thilo van Eimeren  2   3   4 , Alexander Drzezga  1   2   4 ; Alzheimer’s Disease Neuroimaging Initiative
Affiliations
Comparative Study

Assessment of Tau Tangles and Amyloid-β Plaques Among Super Agers Using PET Imaging

Merle C Hoenig et al. JAMA Netw Open. .

Abstract

This cross-sectional study examines positron emission tomography (PET) imaging to investigate the burden of tau tangles and amyloid β plaques in super agers, normal agers, and patients with mild cognitive impairment vs younger amyloid-negative controls.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr van Eimeren reported receiving consulting and lecture fees from Lundbeck A/S, Lilly Germany, and Shire Germany and research funding from the German Research Foundation (DFG), the Leibniz Association, and the EU-joint program for neurodegenerative disease research (JPND). Dr Drzezga reported receiving research support and speaker honoraria by Life Molecular Imaging, AVID/Lilly Radiopharmaceuticals, Siemens Healthineers, and GE Healthcare. No other disclosures were reported.

Figures

Figure.
Figure.. Global and Regional Tau Tangles and Amyloid β Plaques for the Super Ager, Normal Ager, and Mild Cognitive Impairment (MCI) Groups
A and B, All brain projections represent the contrast of the respective group against the younger healthy cognitively normal group (P < .0001, uncorrected). C and D, Box plots show significant differences between regional standard uptake value ratios (SUVRs) of the 4 groups. Lines within boxes denote medians, tops and bottoms of boxes denote 75th and 25th percentiles, error bars denote 95% CIs, and circles denote outliers. Benjamini Hochberg corrected P value threshold was P ≤ .022 for tau burden and P ≤ .007 for amyloid burden. aComparison of respective group vs younger healthy control group. bComparison of super agers vs normal agers.
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