Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I

Fertil Steril. 2021 Jan;115(1):54-61. doi: 10.1016/j.fertnstert.2020.11.015. Epub 2020 Dec 9.


Purpose: The summary presented herein represents Part I of the two-part series dedicated to the Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline. Part I outlines the appropriate evaluation of the male in an infertile couple. Recommendations proceed from obtaining an appropriate history and physical exam (Appendix I), as well as diagnostic testing, where indicated.

Materials/methods: The Emergency Care Research Institute Evidence-based Practice Center team searched PubMed®, Embase®, and Medline from January, 2000 through May, 2019. When sufficient evidence existed, the body of evidence was assigned a strength rating of A (high), B (moderate), or C (low) for support of Strong, Moderate, or Conditional Recommendations. In the absence of sufficient evidence, additional information is provided as Clinical Principles and Expert Opinions. (Table 1) This summary is being simultaneously published in Fertility and Sterility and The Journal of Urology.

Results: This Guideline provides updated, evidence-based recommendations regarding evaluation of male infertility as well as the association of male infertility with other important health conditions. The detection of male infertility increases the risk of subsequent development of health problems for men. In addition, specific medical conditions are associated with some causes for male infertility. Evaluation and treatment recommendations are summarized in the associated algorithm. (Figure 1) CONCLUSION: The presence of male infertility is crucial to the health of patients and its effects must be considered for the welfare of society. This document will undergo updating as the knowledge regarding current treatments and future treatment options continues to expand.

Keywords: Male infertility; chemotherapy; evaluation; health; surgery.

Publication types

  • Practice Guideline

MeSH terms

  • Adult
  • Endocrinology / methods
  • Endocrinology / organization & administration
  • Endocrinology / standards*
  • Evidence-Based Practice / organization & administration
  • Evidence-Based Practice / standards*
  • Female
  • Humans
  • Infertility, Male / diagnosis*
  • Infertility, Male / therapy*
  • Male
  • Pregnancy
  • Reproductive Medicine / methods
  • Reproductive Medicine / organization & administration
  • Reproductive Medicine / standards*
  • Societies, Medical / standards
  • Urology / methods
  • Urology / organization & administration
  • Urology / standards*