Higher intelligence may be a risk factor for postoperative transient disturbance of consciousness after corpus callosotomy

Epilepsy Behav. 2021 Feb;115:107617. doi: 10.1016/j.yebeh.2020.107617. Epub 2020 Dec 11.


Introduction: Corpus callosotomy (CC) is an established surgical option for palliative treatment of medically intractable epilepsy, especially for seizures with drop attacks. We postulated that specific risk factors for post-CC transient disturbance of consciousness (pCTDC) are associated with CC. The purpose of this study was to review patients with intractable epilepsy who underwent CC and to statistically analyze risk factors for pCTDC.

Methods: Inclusion criteria for patients who underwent CC between January 2009 and November 2019 were: (1) ≥2 years old and (2) followed up for more than 8 months. The state of consciousness before and after CC was evaluated with the Glasgow coma scale. We statistically assessed predictors for pCTDC as the primary outcome.

Results: Fifty-six patients (19 females, 37 males) were enrolled, and the age range was 2-57 years old. Thirty-seven (66.1%) patients developed pCTDC. The mean period from the beginning of the state of pCTDC to recovery to their baseline conscious level was 4.9 days (range: 2-25 days). All three (100%) normal intelligence level patients, 13 (81%) of 16 patients with a moderately impaired level of intelligence, and 21 (57%) of 37 patients with a severely impaired level of intelligence exhibited pCTDC. Univariate (p = 0.044) and multivariate (p = 0.006) logistic regression analyses for predictors of pCTDC showed that intellectual function was statistically significant.

Conclusion: Two-thirds of patients developed pCTDC. One risk factor for pCTDC may be higher intellectual function.

Keywords: Corpus callosotomy; Disconnection syndrome; Glasgow coma scale; Intellectual function; Post-corpus callosotomy transient disturbance of consciousness.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Consciousness*
  • Corpus Callosum*
  • Female
  • Humans
  • Intelligence
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Young Adult