Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer

Snehal Nirgude; Bibha Choudhary

doi:10.1016/j.bcp.2020.114365

Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer

Biochem Pharmacol. 2021 Feb:184:114365. doi: 10.1016/j.bcp.2020.114365. Epub 2020 Dec 11.

Authors

Snehal Nirgude¹, Bibha Choudhary²

Affiliations

¹ Institute of Bioinformatics and Applied Biotechnology, Electronic City Phase 1, Bangalore 560100, India; Registered as graduate student under Manipal Academy of Higher Education, Manipal 576104, India.
² Institute of Bioinformatics and Applied Biotechnology, Electronic City Phase 1, Bangalore 560100, India. Electronic address: vibha@ibab.ac.in.

PMID: 33310051
DOI: 10.1016/j.bcp.2020.114365

Abstract

Glutathione peroxidases are well known antioxidant enzymes. They catalyze the reduction of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 GPxs, GPx3, a highly conserved protein and a major ROS scavenger in plasma, has been well studied and confirmed to play a vital role as a tumor suppressor in most cancers. Additionally, this gene is known to be epigenetically regulated. It is downregulated either by hypermethylation or genomic deletion. In this review, we summarized the role of GPX3 in various cancers, its use as a prognostic biomarker, and a potential target for clinical intervention.

Keywords: Biomarker; Glutathione peroxidase; Hypermethylation; Therapeutic.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antioxidants / metabolism*
Cell Movement
Drug Resistance, Neoplasm / physiology
Glutathione Peroxidase / blood
Glutathione Peroxidase / genetics
Glutathione Peroxidase / metabolism*
Humans
Inflammation / metabolism
Mice
Mutation
Neoplasms / metabolism*
Neoplasms / pathology
Polymorphism, Single Nucleotide

Substances

Antioxidants
GPX3 protein, human
Gpx3 protein, mouse
Glutathione Peroxidase