Prostate adenocarcinoma of secretory type with wide expression of p63 and negativity of the basal marker Ck5/6: Rare subtype of adenocarcinoma of secretory origin and to be differentiated from basal cell carcinoma. Review of literature

Rare Tumors. 2020 Dec 1;12:2036361320971948. doi: 10.1177/2036361320971948. eCollection 2020.


We report a case of prostate carcinoma with wide nuclear expression for p63. These cases are rare and show atypical cytoplasmic/membrane expression of Ck5/6, alpha-methylacyl coenzyme A racemase and high-molecular-weight cytokeratin. It is rare to find this type of carcinoma with negativity for Ck5/6. We would like to present this case to avoid a diagnostic pitfall and with review of literature to understand the origin of this rare subtype.

Keywords: Rare subtype; basal-like pattern; negativity to Ck5/6; positivity of P63; prostate adenocarcinoma.

Publication types

  • Case Reports