Rare case of acinar cell carcinoma with multiple lesions in the pancreas

Yuki Ikeda; Makoto Yoshida; Kazuma Ishikawa; Tomohiro Kubo; Yasutoshi Kimura; Tadashi Hasegawa; Koji Miyanishi; Junji Kato

doi:10.1002/jgh3.12380

Rare case of acinar cell carcinoma with multiple lesions in the pancreas

JGH Open. 2020 Jun 29;4(6):1242-1243. doi: 10.1002/jgh3.12380. eCollection 2020 Dec.

Authors

Yuki Ikeda¹, Makoto Yoshida¹, Kazuma Ishikawa¹, Tomohiro Kubo¹, Yasutoshi Kimura², Tadashi Hasegawa³, Koji Miyanishi¹, Junji Kato¹

Affiliations

¹ Department of Medical Oncology Sapporo Medical University Sapporo Japan.
² Department of Surgery, Surgical Oncology and Science Sapporo Medical University Sapporo Japan.
³ Department of Surgical Pathology Sapporo Medical University Sapporo Japan.

Abstract

We present the first case of pancreatic acinar cell carcinoma (PACC) with multiple lesions. A 55-year-old man with a pancretic tail mass on abdominal computed tomography (CT) was admitted to our hospital. Endoscopic ultrasound (EUS) showed a hypoechoic mass, and EUS-guided fine-needle aspiration (EUS-FNA) revealed the mass to be PACC. The patient underwent distal pancreatectomy, and two masses were identified in the pancreatic tail and body. Histologically, both masses had tumor cells similar to acinar cells and were positive for BCL-10. The patient was thus diagnosed with synchronous PACC. Ten months after the surgery, abdominal CT revealed a mass in the remnant pancreas. EUS showed a hypoechoic mass, and EUS-FNA determined it to be PACC. The patient underwent total remnant pancreatectomy. The histological imaging results were similar to those of the first resection. Finally, the patient was diagnosed with synchronous and metachronous PACC. The possibility of multiple occurrences in the pancreas should be considered with PACC.

Keywords: acinar cell carcinoma; metachronous; pancreatic cancer; synchronous.

Publication types

Case Reports