Uniform spatial pooling explains topographic organization and deviation from receptive-field scale invariance in primate V1

Nat Commun. 2020 Dec 15;11(1):6390. doi: 10.1038/s41467-020-19954-9.

Abstract

Receptive field (RF) size and preferred spatial frequency (SF) vary greatly across the primary visual cortex (V1), increasing in a scale invariant fashion with eccentricity. Recent studies reveal that preferred SF also forms a fine-scale periodic map. A fundamental open question is how local variability in preferred SF is tied to the overall spatial RF. Here, we use two-photon imaging to simultaneously measure maps of RF size, phase selectivity, SF bandwidth, and orientation bandwidth-all of which were found to be topographically organized and correlate with preferred SF. Each of these newly characterized inter-map relationships strongly deviate from scale invariance, yet reveal a common motif-they are all accounted for by a model with uniform spatial pooling from scale invariant inputs. Our results and model provide novel and quantitative understanding of the output from V1 to downstream circuits.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Mapping
  • Calcium
  • Eye Movements
  • Macaca mulatta
  • Male
  • Models, Biological
  • Orientation
  • Photic Stimulation / methods
  • Primates
  • Visual Cortex / diagnostic imaging*
  • Visual Cortex / physiology*
  • Visual Fields / physiology*

Substances

  • Calcium