Abstract
The orally active hypoxia inducible factor-proly hydroxylase (HIF-PH) inhibitor enarodustat (ENAROY®, Japan Tobacco) is being developed as an alternative to injectable erythropoietin stimulating agents such as epoetin and darbepoetin for the treatment of anaemia associated with chronic kidney disease (CKD). The drug is approved in Japan and clinical development is ongoing in the USA and South Korea. This article summarizes the milestones in the development of enarodustat leading to this first approval for anaemia associated with CKD.
MeSH terms
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Anemia / drug therapy*
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Anemia / metabolism
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Humans
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Hypoxia-Inducible Factor-Proline Dioxygenases / analysis*
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Hypoxia-Inducible Factor-Proline Dioxygenases / metabolism
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Molecular Structure
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N-substituted Glycines / administration & dosage
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N-substituted Glycines / pharmacology*
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Prolyl-Hydroxylase Inhibitors / administration & dosage
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Prolyl-Hydroxylase Inhibitors / chemistry
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Prolyl-Hydroxylase Inhibitors / pharmacology*
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Pyridines / administration & dosage
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Pyridines / pharmacology*
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Renal Insufficiency, Chronic / drug therapy*
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Renal Insufficiency, Chronic / metabolism
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Republic of Korea
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Triazoles / administration & dosage
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Triazoles / pharmacology*
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United States
Substances
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N-substituted Glycines
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Prolyl-Hydroxylase Inhibitors
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Pyridines
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Triazoles
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Hypoxia-Inducible Factor-Proline Dioxygenases
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enarodustat