Toward Antibacterial Coatings for Personalized Implants

ACS Biomater Sci Eng. 2020 Oct 12;6(10):5486-5492. doi: 10.1021/acsbiomaterials.0c00683. Epub 2020 Sep 10.

Abstract

The complex reconstructive surgeries for which patient-specific orthopedic, maxillofacial, or dental implants are used often necessitate wounds that are open for a considerable amount of time. Unsurprisingly, this allows bacteria to establish implant-associated infection, despite the scrupulous sterilization efforts made during surgery. Here, we developed a prophylactic bactericidal coating via electrophoretic deposition technology for two 3D-printed porous titanium implant designs. The surface characteristics, antibiotic release behavior, antibacterial properties, and impact on osteoblast cell proliferation of the optimized coatings were investigated. The results unequivocally confirmed the biofunctionality of the implants in vitro. This study reveals a new avenue for future antibacterial patient-specific implants.

Keywords: antibacterial coating; metal 3D printing; personalized implants.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents*
  • Coated Materials, Biocompatible*
  • Humans
  • Prostheses and Implants
  • Titanium

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Coated Materials, Biocompatible
  • Titanium