Graft-versus-leukemia following bone marrow transplantation

Bone Marrow Transplant. 1987 Oct;2(3):233-42.


Considerable data in animals suggest an anti-leukemia reaction associated with transplantation of allogeneic bone marrow cells. In some instances, this graft-versus leukemia (GVL) reaction may be distinct from graft-versus-host-disease (GVHD). Data in humans also support the concept of a GVL effect associated with bone marrow transplantation. These observations include an increased risk of leukemia relapse in identical twin transplants and in recipients of T cell-depleted allogeneic transplants, and a decreased risk-of leukemia relapse in individuals who develop acute or chronic GVHD. These findings are among the most convincing evidence that the immune system plays a role against cancer in man.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Marrow Transplantation*
  • Graft vs Host Disease / immunology
  • Humans
  • Leukemia / immunology
  • Leukemia / therapy*
  • T-Lymphocytes / immunology
  • Twins, Monozygotic