Nuclear pore complexes in development and tissue homeostasis

Development. 2020 Dec 15;147(23):dev183442. doi: 10.1242/dev.183442.


Nuclear pore complexes are multiprotein channels that span the nuclear envelope, which connects the nucleus to the cytoplasm. In addition to their main role in the regulation of nucleocytoplasmic molecule exchange, it has become evident that nuclear pore complexes and their components also have multiple transport-independent functions. In recent years, an increasing number of studies have reported the involvement of nuclear pore complex components in embryogenesis, cell differentiation and tissue-specific processes. Here, we review the findings that highlight the dynamic nature of nuclear pore complexes and their roles in many cell type-specific functions during development and tissue homeostasis.

Keywords: Differentiation; Embryogenesis; Nuclear pore complex; Nucleocytoplasmic transport; Tissue homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Cell Nucleus / genetics*
  • Cytoplasm / genetics
  • Embryonic Development / genetics
  • Homeostasis / genetics*
  • Humans
  • Nuclear Envelope / genetics
  • Nuclear Pore / genetics*
  • Nuclear Pore Complex Proteins / genetics*
  • Organ Specificity / genetics


  • Nuclear Pore Complex Proteins