The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population

Yangong Wang; Yiran Xu; Yangyi Fan; Dan Bi; Juan Song; Lei Xia; Qing Shang; Chao Gao; Xiaoli Zhang; Dengna Zhu; Yimeng Qiao; Yu Su; Xiaoyang Wang; Changlian Zhu; Qinghe Xing

doi:10.3389/fnins.2020.590098

The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population

Front Neurosci. 2020 Nov 25:14:590098. doi: 10.3389/fnins.2020.590098. eCollection 2020.

Authors

Yangong Wang¹, Yiran Xu², Yangyi Fan¹, Dan Bi³, Juan Song², Lei Xia², Qing Shang⁴, Chao Gao⁴, Xiaoli Zhang², Dengna Zhu⁵, Yimeng Qiao¹, Yu Su¹, Xiaoyang Wang², Changlian Zhu^{2

6

7}, Qinghe Xing^{1

8}

Affiliations

¹ Institutes of Biomedical Science and Children's Hospital, Fudan University, Shanghai, China.
² Henan Key Laboratory of Child Brain Injury, Department of Pediatrics, The 3rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Zhengzhou, China.
³ Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
⁴ Department of Pediatrics, Children's Hospital of Zhengzhou University and Henan Children's Hospital, Zhengzhou, China.
⁵ Child Rehabilitation Center, The 3rd Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁶ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
⁷ Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
⁸ Shanghai Center for Women and Children's Health, Shanghai, China.

Abstract

Background: Cerebral palsy (CP) is a syndrome of non-progressive motor dysfunction caused by early brain development injury. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP. Methods: We recruited 782 children with CP as the case group and 770 healthy children as the control group. The association between IL-23R single nucleotide polymorphisms (SNPs; namely, rs10889657, rs6682925, rs1884444, rs17375018, rs1004819, rs11805303, and rs10889677) and CP was studied by using a case-control method and SHEsis online software. Subgroup analysis based on complications and clinical subtypes was also carried out. Results: There were differences in the allele and genotype frequencies between CP cases and controls at the rs11805303 and rs10889677 SNPs (Pallele = 0.014 and 0.048, respectively; Pgenotype = 0.023 and 0.008, respectively), and the difference in genotype frequency of rs10889677 remained significant after Bonferroni correction (Pgenotype = 0.048). Subgroup analysis revealed a more significant association of rs10889677 with CP accompanied by global developmental delay (Pgenotype = 0.024 after correction) and neonatal encephalopathy (Pgenotype = 0.024 after correction). Conclusion: The present results showed a significant association between IL-23R and CP, suggesting that IL-23R may play a potential role in CP pathogenesis.

Keywords: IL23R; cerebral palsy; gene polymorphism; inflammatory cytokines; interleukin.