In Vivo Positron Emission Tomography Imaging of Adenosine A2A Receptors

Meng-Juan Sun; Fang Liu; Ya-Fei Zhao; Xiao-Ai Wu

doi:10.3389/fphar.2020.599857

In Vivo Positron Emission Tomography Imaging of Adenosine A_2A Receptors

Front Pharmacol. 2020 Nov 26:11:599857. doi: 10.3389/fphar.2020.599857. eCollection 2020.

Authors

Meng-Juan Sun^{1

2}, Fang Liu³, Ya-Fei Zhao^{1

2}, Xiao-Ai Wu⁴

Affiliations

¹ Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² Acupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu, China.
³ Department of Laboratory Pathology, Xijing Hospital, Fourth Military Medical University, Xian, China.
⁴ Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.

Abstract

As an invasive nuclear medical imaging technology, positron emission tomography (PET) possess the possibility to imaging the distribution as well as the density of selective receptors via specific PET tracers. Inspired by PET, the development of radio-chemistry has greatly promoted the progress of innovative imaging PET tracers for adenosine receptors, in particular adenosine A2A receptors (A_2ARs). PET imaging of A2A receptors play import roles in the research of adenosine related disorders. Several radio-tracers for A_2A receptors imaging have been evaluated in human studies. This paper reviews the recent research progress of PET tracers for A2A receptors imaging, and their applications in the diagnosis and treatment of related disease, such as cardiovascular diseases, autoimmune diseases, neurodegenerative and psychiatric disease. The future development of A2A PET tracers were also discussed.

Keywords: adenosine A2A receptors; autoimmune diseases; cardiovascular diseases; neurodegenerative and psychiatric disease; positron emission tomography imaging; positron emission tomography tracers.

Publication types

Review