Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Relapse With COVID-19

Front Neurol. 2020 Nov 25:11:598531. doi: 10.3389/fneur.2020.598531. eCollection 2020.


A 39-year-old lady with relapsing myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease developed coryzal symptoms, malaise, sweating, and postural dizziness. Six days later she presented with painful progressive right visual loss consistent with optic neuritis. COVID-19 was confirmed by nasopharyngeal swab and MOG-IgG serological reversion was noted. Visual function improved following steroids and plasma exchange. This case highlights a possible causal association between inflammation due to COVID-19 and a relapse of MOG-IgG associated disease. It also highlights the clinical relevance of reporting MOG-IgG titers in MOG-IgG associated disease.

Keywords: Devic's disease; autoimmune diseases; myelin-oligodendrocyte glycoprotein (MOG); optic neuritis; post-infectious; visual loss.

Publication types

  • Case Reports