Efficacy of prolotherapy and arthrocentesis in management of temporomandibular joint hypermobility

Cranio. 2023 Sep;41(5):423-431. doi: 10.1080/08869634.2020.1861887. Epub 2020 Dec 16.


Objective: The aim of this study was to compare the efficacy of dextrose prolotherapy in conjunction with arthrocentesis and dextrose prolotherapy alone in the management of symptomatic TMJ hypermobility.

Methods: Twenty-four patients suffering from TMJ symptomatic hypermobility received 10% dextrose injections for three sessions at four-week intervals. Twelve patients (P group) received prolotherapy alone; the other 12 (PA group) also underwent a single arthrocentesis session. Patients were evaluated for maximal incisal opening, maximal incisal opening without pain, pain at rest, pain during chewing function, TMJ sound, and locking episode frequency.

Results: Pain scores were significantly reduced in both groups, and the locking episode frequency was decreased to a greater extent in the PA than the P group, at both the short and long terms.

Conclusion: Prolotherapy is effective in the management of TMJ hypermobility. However, prolotherapy with arthrocentesis may be superior to prolotherapy alone in the management of TMJ hypermobility.

Keywords: Prolotherapy; arthrocentesis; temporomandibular joint.

MeSH terms

  • Arthrocentesis
  • Glucose / therapeutic use
  • Humans
  • Injections, Intra-Articular
  • Pain
  • Prolotherapy*
  • Range of Motion, Articular
  • Temporomandibular Joint
  • Temporomandibular Joint Disorders*
  • Treatment Outcome


  • Glucose