The disposition of bunolol in the rabbit eye

J Ocul Pharmacol. Summer 1987;3(2):149-57. doi: 10.1089/jop.1987.3.149.

Abstract

Following topical administration to albino rabbits, bunolol hydrochloride, a beta 1- and beta 2-adrenoceptor antagonist, was rapidly absorbed and distributed in ocular tissues, and transformed intraocularly to a single metabolite, dihydrobunolol. The half-life of bunolol was approximately 1.26 hours in the aqueous humor and 1.63 hours in the ciliary body. There was no significant accumulation of bunolol during a four-day period of twice-daily dosing. Most of the drug was excreted in the urine following ocular or intravenous administration.

MeSH terms

  • Absorption
  • Administration, Topical
  • Animals
  • Biotransformation
  • Eye / metabolism*
  • Female
  • Levobunolol / pharmacokinetics*
  • Levobunolol / urine
  • Rabbits
  • Tissue Distribution

Substances

  • Levobunolol