Neuromolecular Mechanisms of Cannabis Action

Adv Exp Med Biol. 2021:1264:15-28. doi: 10.1007/978-3-030-57369-0_2.

Abstract

Most of our current understanding of the neuromolecular mechanisms of Cannabis action focusses on two plant cannabinoids, THC and CBD. THC acts primarily through presynaptic CB cannabinoid receptors to regulate neurotransmitter release in the brain, spinal cord and peripheral nerves. CBD action, on the other hand, is probably mediated through multiple molecular targets.

Keywords: cannabidiol; cannabinoid receptors; Δ9-Tetrahydrocannabinol.

Publication types

  • Review

MeSH terms

  • Cannabidiol / pharmacology
  • Cannabinoids / pharmacology*
  • Cannabis / chemistry*
  • Dronabinol / pharmacology
  • Humans
  • Neurotransmitter Agents / metabolism
  • Receptors, Cannabinoid / metabolism
  • Synaptic Transmission / drug effects*

Substances

  • Cannabinoids
  • Neurotransmitter Agents
  • Receptors, Cannabinoid
  • Cannabidiol
  • Dronabinol