Continuous Renal Replacement Therapy with oXiris® Membrane in Severe Ebstein-Barr Virus-Mediated Hemophagocytic Lymphohistiocytosis: A Case Report

Blood Purif. 2021;50(4-5):578-581. doi: 10.1159/000511724. Epub 2020 Dec 17.


Hemophagocytic lymphohistiocytosis (HLH), a life-threatening disease with uncontrolled immune activation and inflammatory reaction, often leads to a deadly cytokine storm. In severe Ebstein-Barr virus-triggered HLH receiving standard immunosuppression, continuous renal replacement therapy (CRRT) with oXiris® blood purification membrane resulted in a timely reduction of inflammatory markers and discontinuation of vasopressors. To our knowledge, this is the first report of successful use of the oXiris® membrane in HLH.

Keywords: Continuous renal replacement therapy; Critical care; Hemophagocytic lymphohistiocytosis; Inflammation; oXiris®.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Continuous Renal Replacement Therapy* / instrumentation
  • Epstein-Barr Virus Infections / complications*
  • Epstein-Barr Virus Infections / therapy
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Lymphohistiocytosis, Hemophagocytic / therapy*
  • Lymphohistiocytosis, Hemophagocytic / virology*
  • Male
  • Young Adult