The Diverse Efficacy of Food-Derived Proanthocyanidins for Middle-Aged and Elderly Women

Nutrients. 2020 Dec 15;12(12):3833. doi: 10.3390/nu12123833.


Middle-aged and elderly women are affected by various symptoms and diseases induced by estrogen deficiency. Proanthocyanidins, widely present in many kinds of fruits and berries, have many beneficial effects, such as antioxidative, anti-inflammatory, and antimicrobial activities. We researched the effects of proanthocyanidins for middle-aged and elderly women, finding that it has been revealed in many clinical trials and cohort studies that proanthocyanidins contribute to the prevention of cardiovascular disease, hypertension, obesity, cancer, osteoporosis, and urinary tract infection, as well as the improvement of menopausal symptoms, renal function, and skin damage. Thus, proanthocyanidins can be considered one of the potent representatives of complementary alternative therapy.

Keywords: cardiovascular disease; cranberry; grape seed; menopause; middle-aged; proanthocyanidin; women.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Eating / physiology*
  • Female
  • Food Analysis
  • Humans
  • Middle Aged
  • Postmenopause / drug effects*
  • Proanthocyanidins / pharmacology*
  • Prospective Studies
  • Randomized Controlled Trials as Topic


  • Proanthocyanidins