Acute Kidney Injury in Sepsis: Evidence From Asia

Kohei Yoshimoto; Yohei Komaru; Masao Iwagami; Kent Doi

doi:10.1016/j.semnephrol.2020.08.005

Acute Kidney Injury in Sepsis: Evidence From Asia

Semin Nephrol. 2020 Sep;40(5):489-497. doi: 10.1016/j.semnephrol.2020.08.005.

Authors

Kohei Yoshimoto¹, Yohei Komaru², Masao Iwagami³, Kent Doi⁴

Affiliations

¹ Department of Acute Medicine, University of Tokyo, Tokyo, Japan.
² Department of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan.
³ Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
⁴ Department of Acute Medicine, University of Tokyo, Tokyo, Japan. Electronic address: kdoi-tky@umin.ac.jp.

PMID: 33334462
DOI: 10.1016/j.semnephrol.2020.08.005

Abstract

Acute kidney injury (AKI) is one of the most frequent complications of sepsis. Because sepsis and AKI synergistically worsen the outcomes of critically ill patients, better therapeutics against septic AKI urgently are required. In addition to the complexity of disease mechanisms of both sepsis and AKI, there is substantial regional variation in clinical practice, which further hampers the development of new treatments for septic AKI. To overcome this problem, evidence accumulation is necessary for building the foundation for developing novel septic AKI treatments. This review provides a summary of updated evidence regarding septic AKI from Asian regions.

Keywords: Acute kidney injury; adsorption; endotoxin adsorption; epidemiology; sepsis.

Publication types

Review

MeSH terms

Acute Kidney Injury* / etiology
Acute Kidney Injury* / therapy
Asia / epidemiology
Critical Illness
Humans
Sepsis* / complications