Polycystic Ovarian Syndrome and Fertility

Clin Obstet Gynecol. 2021 Mar 1;64(1):65-75. doi: 10.1097/GRF.0000000000000595.


Polycystic ovary syndrome (PCOS) is a common endocrinopathy that has been associated with impaired fertility. This chapter reviews the underlying pathophysiology of PCOS and the associated fertility barriers of the condition. Psychologic concerns, hypothalamic-pituitary, ovarian, and mitochondria dysfunction, obesity, and the role of vitamin D in PCOS are considered with respect to fertility. Lastly, pregnancy risk factors associated with PCOS are also reviewed.

MeSH terms

  • Female
  • Fertility
  • Humans
  • Obesity / complications
  • Polycystic Ovary Syndrome* / complications
  • Pregnancy
  • Vitamin D


  • Vitamin D