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Review
. 2021 Dec 6;73(11):e4223-e4228.
doi: 10.1093/cid/ciaa1866.

Reinfection With SARS-CoV-2: Implications for Vaccines

Jeffrey I Cohen  1 , Peter D Burbelo  2
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Free PMC article
Review

Reinfection With SARS-CoV-2: Implications for Vaccines

Jeffrey I Cohen et al. Clin Infect Dis. .
Free PMC article

Abstract

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become pandemic and the duration of protective immunity to the virus is unknown. Cases of persons reinfected with the virus are being reported with increasing frequency. At present it is unclear how common reinfection with SARS-CoV-2 is and how long serum antibodies and virus-specific T cells persist after infection. For many other respiratory virus infections, including influenza and the seasonal coronaviruses that cause colds, serum antibodies persist for only months to a few years and reinfections are very common. Here we review what is known about the duration of immunity and reinfection with coronaviruses, including SARS-CoV-2, as well as the duration of immunity to other viruses and virus vaccines. These findings have implications for the need of continued protective measures and for vaccines for persons previously infected with SARS-CoV-2.

Keywords: COVID-19; SARS; SARS-CoV-2; coronavirus; reinfection.

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References

    1. Carfì A, Bernabei R, Landi F; Gemelli Against COVID-19 Post-Acute Care Study Group . Persistent symptoms in patients after acute COVID-19. JAMA 2020; 324:603–5. - PMC - PubMed
    1. Slifka MK, Ahmed R. Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity. Trends Microbiol 1996; 4:394–400. - PMC - PubMed
    1. Amanna IJ, Carlson NE, Slifka MK. Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med 2007; 357:1903–15. - PubMed
    1. Leblanc JF, Germain M, Delage G, OʼBrien S, Drews SJ, Lewin A. Risk of transmission of severe acute respiratory syndrome coronavirus 2 by transfusion: a literature review. Transfusion 2020; 60:3046–54. - PMC - PubMed
    1. Mo H, Zeng G, Ren X, et al. . Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance. Respirology 2006; 11:49–53. - PMC - PubMed

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