RNA-ligant interactions. (I) Magnesium binding sites in yeast tRNAPhe

Nucleic Acids Res. 1977 Aug;4(8):2811-20. doi: 10.1093/nar/4.8.2811.


X-ray crystallagraphic studies studies indicate that there are at least four site-specifically bound hydrated Mg2+ ions, [Mg(H2O)n]2+, in yeast tRNAPhe. The size and the octahedral coordination geometry, rather than the charge, of [Mg(H2O)N]2+ appear to be the primary reasons for the specificity of magnesium ions in site-binding and in the stabilization of the tertiary structure of tRNA.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Binding Sites
  • Chemical Phenomena
  • Chemistry
  • Ligands
  • Magnesium*
  • Models, Molecular
  • Nucleic Acid Conformation
  • Phenylalanine
  • RNA, Transfer*
  • Saccharomyces cerevisiae
  • X-Ray Diffraction


  • Ligands
  • Phenylalanine
  • RNA, Transfer
  • Magnesium