Complications and Pathophysiology of COVID-19 in the Nervous System

Haiyang Yu; Tong Sun; Juan Feng

doi:10.3389/fneur.2020.573421

Complications and Pathophysiology of COVID-19 in the Nervous System

Front Neurol. 2020 Dec 4:11:573421. doi: 10.3389/fneur.2020.573421. eCollection 2020.

Authors

Haiyang Yu¹, Tong Sun², Juan Feng¹

Affiliations

¹ Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
² Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Abstract

The coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global public health threat. Majority of the patients with COVID-19 have fever, cough, and fatigue. Critically ill patients can develop dyspnea and acute respiratory distress syndrome. In addition to respiratory symptoms, neurological damage also occurs in some patients. However, the mechanisms by which SARS-CoV-2 invades the nervous system have not been elucidated yet. In order to provide some reference for designing optimal therapeutic strategies, we have discussed the complications and potential mechanisms of COVID-19 in the nervous system in this review.

Keywords: COVID-19; SARS-CoV-2; complication; coronavirus; nervous system; pathophysiology.

Publication types

Review