Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes

Pulm Circ. 2020 Dec 7;10(4):2045894020968531. doi: 10.1177/2045894020968531. eCollection Oct-Dec 2020.

Abstract

Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.

Keywords: PBMC; RNAseq; pulmonary arterial hypertension; transcriptome profiling.