Neurovascular inflammation in the pathogenesis of brain arteriovenous malformations

doi:10.1002/jcp.30226

Review

. 2021 Jul;236(7):4841-4856.

doi: 10.1002/jcp.30226. Epub 2020 Dec 20.

Neurovascular inflammation in the pathogenesis of brain arteriovenous malformations

S Krithika¹, S Sumi¹

Affiliations

PMID: 33345330
DOI: 10.1002/jcp.30226

Review

Neurovascular inflammation in the pathogenesis of brain arteriovenous malformations

S Krithika et al. J Cell Physiol. 2021 Jul.

. 2021 Jul;236(7):4841-4856.

doi: 10.1002/jcp.30226. Epub 2020 Dec 20.

Authors

S Krithika¹, S Sumi¹

Affiliation

¹ Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.

PMID: 33345330
DOI: 10.1002/jcp.30226

Abstract

Brain arteriovenous malformations (bAVM) arise as congenital or sporadic focal lesions with a significant risk for intracerebral hemorrhage (ICH). A wide range of interindividual differences is present in the onset, progression, and severity of bAVM. A growing body of gene expression and polymorphism-based research studies support the involvement of localized inflammation in bAVM disease progression and rupture. In this review article, we analyze the altered responses of neural, vascular, and immune cell types that contribute to the inflammatory process, which exacerbates the pathophysiological progression of vascular dysmorphogenesis in bAVM lesions. The cumulative effect of inflammation in bAVM development is orchestrated by various genetic moderators and inflammatory mediators. We also discuss the potential therapies for the treatment of brain AVM by targeting the inflammatory processes and mediators. Elucidating the precise role of inflammation in the bAVM growth and hemorrhage would open novel avenues for noninvasive and effectual causal therapy that may complement the current therapeutic strategies.

Keywords: arteriovenous malformations; brain AVM; hereditary hemorrhagic telangiectasia; intracerebral hemorrhage; neuroinflammation.

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Methodological quality assessment of genetic studies on brain arteriovenous malformation related hemorrhage: A cross-sectional study.
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Karthika CL, Venugopal V, Sreelakshmi BJ, Krithika S, Thomas JM, Abraham M, Kartha CC, Rajavelu A, Sumi S. Karthika CL, et al. Cell Mol Biol Lett. 2023 Mar 18;28(1):22. doi: 10.1186/s11658-023-00436-x. Cell Mol Biol Lett. 2023. PMID: 36934253 Free PMC article.

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References

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1. Achroll, A. S., Kim, H., Pawlikowska, L., Trudy Poon, K. Y., McCulloch, C. E., Ko, N. U., Johnston, S. C., McDermott, M. W., Zaroff, J. G., Lawton, M. T., Kwok, P. Y., & Young, W. L. (2007). Association of tumor necrosis factor-α-238G$$ A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Neurosurgery, 61(4), 731-740. https://doi.org/10.1227/01.NEU.0000298901.61849.A4
1. Amati, L., Passeri, M. E., Resta, F., Triggiani, V., Jirillo, E., & Sabbà, C. (2006). Ablation of T-helper 1 cell derived cytokines and of monocyte-derived tumor necrosis factor-α in hereditary hemorrhagic telangiectasia: Immunological consequences and clinical considerations. Current Pharmaceutical Design, 12(10), 1201-1208. https://doi.org/10.2174/138161206776361372
1. Anbarasen, L., Lim, J., Rajandram, R., Mun, K. S., & Sia, S. F. (2019). Expression of osteopontin, matrix metalloproteinase-2 and -9 proteins in vascular instability in brain arteriovenous malformation. PeerJ (Corta Madera, CA and London), 7, e7058. https://doi.org/10.7717/peerj.7058
1. Aziz, M. M., Takagi, Y., Hashimoto, N., & Miyamoto, S. (2010). Activation of nuclear factor κB in cerebral arteriovenous malformations. Neurosurgery, 67(6), 1669-1680. https://doi.org/10.1227/NEU.0b013e3181fa00f1
1. Baeyensens, N., Larrivée, B., Ola, R., Hayward-Piatkowskyi, B., Dubrac, A., Huang, B., Ross, T. D., Coon, B. G., Min, E., Tsarfati, M., Tong, H., Eichmann, A., & Schwartz, M. A. (2016). Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. Journal of Cell Biology, 214(7), 807-816. https://doi.org/10.1083/jcb.201603106

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[1] Achroll, A. S., Kim, H., Pawlikowska, L., Trudy Poon, K. Y., McCulloch, C. E., Ko, N. U., Johnston, S. C., McDermott, M. W., Zaroff, J. G., Lawton, M. T., Kwok, P. Y., & Young, W. L. (2007). Association of tumor necrosis factor-α-238G$$ A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Neurosurgery, 61(4), 731-740. https://doi.org/10.1227/01.NEU.0000298901.61849.A4

[2] Achroll, A. S., Kim, H., Pawlikowska, L., Trudy Poon, K. Y., McCulloch, C. E., Ko, N. U., Johnston, S. C., McDermott, M. W., Zaroff, J. G., Lawton, M. T., Kwok, P. Y., & Young, W. L. (2007). Association of tumor necrosis factor-α-238G$$ A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Neurosurgery, 61(4), 731-740. https://doi.org/10.1227/01.NEU.0000298901.61849.A4

[3] Amati, L., Passeri, M. E., Resta, F., Triggiani, V., Jirillo, E., & Sabbà, C. (2006). Ablation of T-helper 1 cell derived cytokines and of monocyte-derived tumor necrosis factor-α in hereditary hemorrhagic telangiectasia: Immunological consequences and clinical considerations. Current Pharmaceutical Design, 12(10), 1201-1208. https://doi.org/10.2174/138161206776361372

[4] Amati, L., Passeri, M. E., Resta, F., Triggiani, V., Jirillo, E., & Sabbà, C. (2006). Ablation of T-helper 1 cell derived cytokines and of monocyte-derived tumor necrosis factor-α in hereditary hemorrhagic telangiectasia: Immunological consequences and clinical considerations. Current Pharmaceutical Design, 12(10), 1201-1208. https://doi.org/10.2174/138161206776361372

[5] Anbarasen, L., Lim, J., Rajandram, R., Mun, K. S., & Sia, S. F. (2019). Expression of osteopontin, matrix metalloproteinase-2 and -9 proteins in vascular instability in brain arteriovenous malformation. PeerJ (Corta Madera, CA and London), 7, e7058. https://doi.org/10.7717/peerj.7058

[6] Anbarasen, L., Lim, J., Rajandram, R., Mun, K. S., & Sia, S. F. (2019). Expression of osteopontin, matrix metalloproteinase-2 and -9 proteins in vascular instability in brain arteriovenous malformation. PeerJ (Corta Madera, CA and London), 7, e7058. https://doi.org/10.7717/peerj.7058

[7] Aziz, M. M., Takagi, Y., Hashimoto, N., & Miyamoto, S. (2010). Activation of nuclear factor κB in cerebral arteriovenous malformations. Neurosurgery, 67(6), 1669-1680. https://doi.org/10.1227/NEU.0b013e3181fa00f1

[8] Aziz, M. M., Takagi, Y., Hashimoto, N., & Miyamoto, S. (2010). Activation of nuclear factor κB in cerebral arteriovenous malformations. Neurosurgery, 67(6), 1669-1680. https://doi.org/10.1227/NEU.0b013e3181fa00f1

[9] Baeyensens, N., Larrivée, B., Ola, R., Hayward-Piatkowskyi, B., Dubrac, A., Huang, B., Ross, T. D., Coon, B. G., Min, E., Tsarfati, M., Tong, H., Eichmann, A., & Schwartz, M. A. (2016). Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. Journal of Cell Biology, 214(7), 807-816. https://doi.org/10.1083/jcb.201603106

[10] Baeyensens, N., Larrivée, B., Ola, R., Hayward-Piatkowskyi, B., Dubrac, A., Huang, B., Ross, T. D., Coon, B. G., Min, E., Tsarfati, M., Tong, H., Eichmann, A., & Schwartz, M. A. (2016). Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. Journal of Cell Biology, 214(7), 807-816. https://doi.org/10.1083/jcb.201603106

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Neurovascular inflammation in the pathogenesis of brain arteriovenous malformations

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Neurovascular inflammation in the pathogenesis of brain arteriovenous malformations

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