Effects of Fentanyl Versus Morphine on Ticagrelor-Induced Platelet Inhibition in Patients With ST-Segment Elevation Myocardial Infarction: The PERSEUS Randomized Trial

Circulation. 2020 Dec 22;142(25):2479-2481. doi: 10.1161/CIRCULATIONAHA.120.049287. Epub 2020 Dec 21.

Authors

Juan F Iglesias¹, Marco Valgimigli², Federico Carbone^{3

4}, Nathalie Lauriers⁵, Pier Giorgio Masci⁵, Sophie Degrauwe¹

Affiliations

¹ Department of Cardiology, Geneva University Hospitals, Switzerland (J.F.I., S.D.).
² Department of Cardiology, Bern University Hospital, Switzerland (M.V.).
³ First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Italy (F.C.).
⁴ IRCCS Ospedale Policlinico San Martino Genoa, Italian Cardiovascular Network, Italy (F.C.).
⁵ Department of Cardiology, Lausanne University Hospital, Switzerland (N.L., P.G.M.).

PMID: 33347326
DOI: 10.1161/CIRCULATIONAHA.120.049287

No abstract available

Keywords: blood platelets; fentanyl; pharmacology; ticagrelor.

Publication types

Comparative Study
Letter
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Analgesics, Opioid / adverse effects*
Blood Platelets / drug effects*
Blood Platelets / metabolism
Drug Interactions
Fentanyl / adverse effects*
Humans
Morphine / adverse effects*
Percutaneous Coronary Intervention* / adverse effects
Platelet Aggregation Inhibitors / administration & dosage
Platelet Aggregation Inhibitors / pharmacokinetics*
Purinergic P2Y Receptor Antagonists / administration & dosage
Purinergic P2Y Receptor Antagonists / pharmacokinetics*
ST Elevation Myocardial Infarction / blood
ST Elevation Myocardial Infarction / diagnosis
ST Elevation Myocardial Infarction / therapy*
Ticagrelor / administration & dosage
Ticagrelor / pharmacokinetics*
Treatment Outcome

Substances

Analgesics, Opioid
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Morphine
Ticagrelor
Fentanyl

Associated data

ClinicalTrials.gov/NCT02531165