Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

Emerg Infect Dis. 2021 Jan;27(1):294-296. doi: 10.3201/eid2701.203527.


Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.

Keywords: Kelch; Plasmodium falciparum; antimicrobial resistance; artemisinin; malaria; mutation; parasites; polymorphism; vector-borne infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials* / pharmacology
  • Antimalarials* / therapeutic use
  • Drug Resistance / genetics
  • Humans
  • Malaria, Falciparum* / drug therapy
  • Malaria, Falciparum* / epidemiology
  • Mutation
  • Plasmodium falciparum / genetics
  • Protozoan Proteins / genetics
  • Rwanda / epidemiology


  • Antimalarials
  • Protozoan Proteins