Plummer Disease

Excerpt

Plummer disease, or toxic multi-nodular goiter (MNG), is a hormonally active MNG with hyperthyroidism. Plummer disease was first described by Henry Plummer, an American physician, in 1913. It consists of more than 1 autonomous thyroid nodule, or 1 or more autonomous nodules together with 1 or more nonautonomous solid, cystic, or mixed (solid and cystic) nodules or numerous small autonomous areas associated with a spectrum of hyperthyroidism ranging from subclinical hyperthyroidism to severe thyrotoxicosis. Autonomous nodules appear hyperactive (hot or warm), and nonautonomous nodules are hypoactive (cold) or normoactive on nuclear medicine thyroid scintigraphy.