Neurological issues in children with COVID-19

Neurosci Lett. 2021 Jan 19;743:135567. doi: 10.1016/j.neulet.2020.135567. Epub 2020 Dec 19.


Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, but serious complications may occur in conjunction with both acute infection and associated phenomena such as the multisystem inflammatory syndrome in children (MIS-C). Neurological symptoms, which have been predominantly reported in adults, range from mild headache to seizure, peripheral neuropathy, stroke, demyelinating disorders, and encephalopathy. Similar to respiratory and cardiac manifestations of COVID-19, neurological complications present differently based on age and underlying comorbidities. This review provides a concise overview of the neurological conditions seen in the context of COVID-19, as well as potential mechanisms and long-term implications of COVID-19 in the pediatric population from literature reviews and primary data collected at NewYork-Presbyterian Morgan Stanley Children's Hospital.

Keywords: COVID-19; Multisystem inflammatory syndrome in children (MIS-C); Pediatrics; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • COVID-19 / complications*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Nervous System Diseases / virology*
  • SARS-CoV-2