OCTA-guided navigated laser therapy for advanced macula neovascularization secondary to age related macular degeneration

Eur J Ophthalmol. 2021 Nov;31(6):3182-3189. doi: 10.1177/1120672120983191. Epub 2020 Dec 22.


Introduction: To evaluate the effects of the Navilas system guided by optical coherence tomography angiography for advanced macular neovascularization (MNV) secondary to age-related macular degeneration (AMD).

Methods: Prospective case-series including nine eyes presenting with advanced MNV with persistence of exudative signs, no longer responding to anti-VEGF therapy, best-corrected visual acuity at least of 1.3 logMar. All patients were treated with Navilas guided by overlaid optical coherence tomography angiography (OCTA) images at the site of branching large neovascular trunks.

Results: Occlusion of large neovascular trunks successfully occurred in all nine included patients. OCTA analysis revealed, at 1 month follow up, MNV total area decreasing from 6.2 ± 3.1 to 2.6 ± 3.4 mm2. At 6 months follow up, mean MNV area was 3.3 ± 3.4 mm2 (p = 0.008).

Conclusion: This preliminary study showed that Navilas treatment guided by OCTA may represent an attractive therapeutic option in advanced neovascular lesions secondary to AMD.

Keywords: Age-related macular degeneration; RETINA; retina - medical therapies; retinal pathology/research; techniques of retinal examination.

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Choroidal Neovascularization*
  • Fluorescein Angiography
  • Humans
  • Laser Therapy*
  • Macula Lutea*
  • Macular Degeneration* / drug therapy
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Wet Macular Degeneration* / complications
  • Wet Macular Degeneration* / diagnosis
  • Wet Macular Degeneration* / drug therapy


  • Angiogenesis Inhibitors