Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters

Recent Pat Nanotechnol. 2021;15(4):351-366. doi: 10.2174/1872210514666201224103010.

Abstract

Background: Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption.

Methods: Extensive information related to nanosuspensions and its associated patents were collected using Pub Med and Google Scholar.

Results: Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are cost-effective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention.

Conclusion: Nanosuspensions play a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, ocular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.

Keywords: Nanosuspension; colloidal; dissolution rate.; high-pressure homogenization; spin coating; stability.

Publication types

  • Review

MeSH terms

  • Administration, Cutaneous
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Nanoparticles*
  • Particle Size
  • Patents as Topic
  • Solubility
  • Suspensions

Substances

  • Suspensions