Overweight, Obesity, and Late-Life Sarcopenia Among Men With Cardiovascular Disease, Israel

Prev Chronic Dis. 2020 Dec 24:17:E164. doi: 10.5888/pcd17.200167.


Introduction: Little is known about the association between obesity and sarcopenia - age-related loss of muscle mass and function - among patients with cardiovascular disease. We investigated the association between overweight, obesity, and sarcopenia among community-dwelling men in Israel with cardiovascular disease.

Methods: A subset of 337 men (mean age at baseline 56.7 [SD, 6.5]) who previously (1990-1997) participated in the Bezafibrate Infarction Prevention trial underwent a neurovascular evaluation as part of the Bezafibrate Infarction Prevention Neurocognitive Study 15.0 (SD, 3.0) years after baseline and a sarcopenia evaluation 19.9 (SD, 1.0) years after baseline. We applied a multinomial logistic model to estimate odds ratios and 95% CIs for 3 categories of sarcopenia: no evidence of sarcopenia (ie, robust), probable sarcopenia, and sarcopenia.

Results: We found sarcopenia among 54.3% of participants with obesity (body mass index [BMI, in kg/m2] ≥30.0), 37.0% of participants who were overweight (25.0 ≤ BMI ≤29.9), and 24.8% of participants with normal weight (BMI 18.5 to 24.9). In a comparison of BMI ≥25.0 and BMI <25.0, adjusting for covariates, the odds ratio of having probable sarcopenia was 3.27 (95% CI, 1.68-6.36) and having sarcopenia was 5.31 (95% CI, 2.50-11.27).

Conclusion: We found a positive association between obesity and late-life sarcopenia and suggest that obesity might be an important modifiable risk factor related to sarcopenia among men with cardiovascular disease.

MeSH terms

  • Body Mass Index
  • Cardiovascular Diseases* / complications
  • Cardiovascular Diseases* / epidemiology
  • Humans
  • Israel / epidemiology
  • Male
  • Middle Aged
  • Obesity* / complications
  • Obesity* / epidemiology
  • Overweight* / epidemiology
  • Risk Factors
  • Sarcopenia* / complications
  • Sarcopenia* / epidemiology