Fighting for Fat: Gluttonous Tumors and Starved T Cells

Joshua H Goodman; Anthony W Ferrante Jr

doi:10.1016/j.cell.2020.11.039

Fighting for Fat: Gluttonous Tumors and Starved T Cells

Cell. 2020 Dec 23;183(7):1739-1741. doi: 10.1016/j.cell.2020.11.039.

Authors

Joshua H Goodman¹, Anthony W Ferrante Jr²

Affiliations

¹ Medical Scientist Training Program, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA; Department of Medicine, Naomi Berrie Diabetes Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA.
² Department of Medicine, Naomi Berrie Diabetes Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA. Electronic address: awf7@cumc.columbia.edu.

PMID: 33357398
DOI: 10.1016/j.cell.2020.11.039

Abstract

In this issue of Cell, Ringel et al. reveal a link between lipid utilization in the tumor microenvironment and anti-tumor immunity in obese mice. These findings provide one explanation for how obesity worsens cancer outcomes and may point to a new metabolic approach to treating some cancers.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Mice
Mice, Obese
Neoplasms*
Obesity
T-Lymphocytes
Tumor Microenvironment*