Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410

Chin J Nat Med. 2020 Dec;18(12):957-960. doi: 10.1016/S1875-5364(20)60040-1.

Abstract

Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives, arthrianhydride A (1) and B (2), along with three known compounds 3-5, were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp. NF2410. The structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data. Furthermore, compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.

Keywords: Grasshopper-associated fungi; Inhibitory activity; SHP2; Secondary metabolites; Structure elucidation.

MeSH terms

  • Anhydrides / isolation & purification
  • Anhydrides / pharmacology*
  • Animals
  • Biological Products / isolation & purification
  • Biological Products / pharmacology
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Fungi / chemistry*
  • Grasshoppers / microbiology*
  • Molecular Structure
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors
  • Secondary Metabolism

Substances

  • Anhydrides
  • Biological Products
  • Enzyme Inhibitors
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11