A review of in vitro and in vivo methods and their correlations to assess mouthfeel of solid oral dosage forms

Abdullah Asiri; Justyna Hofmanová; Hannah Batchelor

doi:10.1016/j.drudis.2020.12.015

A review of in vitro and in vivo methods and their correlations to assess mouthfeel of solid oral dosage forms

Drug Discov Today. 2021 Mar;26(3):740-753. doi: 10.1016/j.drudis.2020.12.015. Epub 2020 Dec 26.

Authors

Abdullah Asiri¹, Justyna Hofmanová², Hannah Batchelor³

Affiliations

¹ School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Faculty of Clinical Pharmacy, Albaha University, Alaqiq, 65779-77388, Saudi Arabia.
² School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
³ Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. Electronic address: Hannah.batchelor@strath.ac.uk.

PMID: 33359115
DOI: 10.1016/j.drudis.2020.12.015

Abstract

This review analyses the relationship between instrumental and human data used to assess the mouthfeel of solid oral dosage forms to provide recommendations on the most appropriate methods to use in future studies.

Publication types

Systematic Review

MeSH terms

Administration, Oral
Adult
Chemistry, Pharmaceutical / methods*
Dosage Forms
Drug Development / methods*
Humans
Perception
Pharmaceutical Preparations / administration & dosage*
Pharmaceutical Preparations / chemistry
Research Design
Sensation
Tablets

Substances

Dosage Forms
Pharmaceutical Preparations
Tablets