Therapeutic advances of miRNAs: A preclinical and clinical update

J Adv Res. 2020 Aug 29;28:127-138. doi: 10.1016/j.jare.2020.08.012. eCollection 2021 Feb.


miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.

Keywords: Biopharmaceuticals; Next-generation medicine; miRNA.

Publication types

  • Review