Letter to the Editor: "Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood"

Robert L Rosenfield

doi:10.1210/jendso/bvaa163

Letter to the Editor: "Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood"

J Endocr Soc. 2020 Nov 7;5(1):bvaa163. doi: 10.1210/jendso/bvaa163. eCollection 2021 Jan 1.

Author

Robert L Rosenfield^{1

2}

Affiliations

¹ The University of Chicago, Pritzker School of Medicine, Departments of Medicine and Pediatrics, Section of Endocrinology, Metabolism, and Diabetes, Chicago, Illinois.
² The University of California, San Francisco, Pediatric Endocrinology, San Francisco, California.

Abstract

The conclusion of Panayiotopoulos et al. that glucocorticoid resistance accounted for 57% to 67% of their premature adrenarche and polycystic ovary syndrome cases cannot be accepted from the data presented. This is because proper validation of their method for determining glucocorticoid sensitivity is not presented. Furthermore, the method seems insensitive to physiologic glucocorticoid concentrations.