Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019

doi:10.1002/ana.26004

. 2021 Mar;89(3):610-616.

doi: 10.1002/ana.26004. Epub 2021 Jan 11.

Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019

Raoul Sutter^{1

2

3

4}, Lisa Hert^{1

2}, Gian Marco De Marchis^{2

3

4}, Raphael Twerenbold^{3

4

5

6}, Ludwig Kappos^{2

3

4

7}, Yvonne Naegelin^{2

3}, Gabriela M Kuster^{5

7}, Pascal Benkert^{4

8}, Jasmine Jost⁹, Aleksandra Maleska Maceski^{2

3

4

7}, Stephan Rüegg^{2

3}, Martin Siegemund^{1

3

4}, David Leppert^{2

3

4

7}, Sarah Tschudin-Sutter^{3

4

10}, Jens Kuhle^{2

3

4

7}

Affiliations

¹ Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
² Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
³ Medical Faculty, University of Basel, Basel, Switzerland.
⁴ Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
⁵ Department of Cardiology, University Hospital Basel, Basel, Switzerland.
⁶ Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
⁷ Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
⁸ Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
⁹ Emergency Department, University Hospital Basel, University of Basel, Basel, Switzerland.
¹⁰ Department of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.

PMID: 33377539
DOI: 10.1002/ana.26004

Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019

Raoul Sutter et al. Ann Neurol. 2021 Mar.

. 2021 Mar;89(3):610-616.

doi: 10.1002/ana.26004. Epub 2021 Jan 11.

Authors

Affiliations

¹ Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
² Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
³ Medical Faculty, University of Basel, Basel, Switzerland.
⁴ Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
⁵ Department of Cardiology, University Hospital Basel, Basel, Switzerland.
⁶ Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
⁷ Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
⁸ Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
⁹ Emergency Department, University Hospital Basel, University of Basel, Basel, Switzerland.
¹⁰ Department of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.

PMID: 33377539
DOI: 10.1002/ana.26004

Abstract

There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89:610-616.

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Comment in

Neurofilament Light Chain in Patients with COVID-19 and Bacterial Pneumonia.
Chung HY, Neu C, Wickel J, Kuckertz SL, Coldewey SM. Chung HY, et al. Ann Neurol. 2021 Jul;90(1):174-175. doi: 10.1002/ana.26135. Epub 2021 Jun 9. Ann Neurol. 2021. PMID: 34036618 Free PMC article. No abstract available.

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References

1. Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-690.
1. Helms J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 2020;382:2268-2270.
1. Li YC, Bai WZ, Hirano N, et al. Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells. Virus Res 2012;163:628-635.
1. Gu J, Gong E, Zhang B, et al. Multiple organ infection and the pathogenesis of SARS. J Exp Med 2005;202:415-424.
1. Xu J, Zhong S, Liu J, et al. Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis. Clin Infect Dis 2005;41:1089-1096.

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[1] Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-690.

[2] Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-690.

[3] Helms J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 2020;382:2268-2270.

[4] Helms J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 2020;382:2268-2270.

[5] Li YC, Bai WZ, Hirano N, et al. Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells. Virus Res 2012;163:628-635.

[6] Li YC, Bai WZ, Hirano N, et al. Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells. Virus Res 2012;163:628-635.

[7] Gu J, Gong E, Zhang B, et al. Multiple organ infection and the pathogenesis of SARS. J Exp Med 2005;202:415-424.

[8] Gu J, Gong E, Zhang B, et al. Multiple organ infection and the pathogenesis of SARS. J Exp Med 2005;202:415-424.

[9] Xu J, Zhong S, Liu J, et al. Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis. Clin Infect Dis 2005;41:1089-1096.

[10] Xu J, Zhong S, Liu J, et al. Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis. Clin Infect Dis 2005;41:1089-1096.

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Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019

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Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019

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