Carbonic anhydrase I and II autoantibody levels in primary hypertension: our preliminary results

Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):12821-12826. doi: 10.26355/eurrev_202012_24183.


Objective: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II autoantibodies have been linked to various autoimmune diseases. However, CA I and II autoantibody levels in primary HT have not been previously investigated. The purpose of this study was, therefore, to investigate levels of CA I and II autoantibodies in primary HT.

Patients and methods: Fifty-six patients newly diagnosed with primary HT and 33 healthy individuals were included in the study. Twenty-four-hour ambulatory blood pressure monitoring was performed following office controls. Blood specimens were collected under appropriate conditions for CA I and II autoantibody level investigation and biochemical tests. Urine sodium and protein excretion were measured after 24 h. Demographic and biochemical parameters and CA I and II autoantibody levels were then compared between the patient and healthy groups.

Results: CA II autoantibody and uric acid levels were significantly higher in the hypertensive group than in the control group (p=0.005, and p<0.001, respectively). CA II autoantibody (exp ß: 79.06 CI: 4.44-1407.02) (p=0.003) and uric acid elevation (exp ß: 2.10 CI: 1.31- 3.34) (p=0.002) were identified as independent predictors of HT development at logistic regression analysis.

Conclusions: CA II autoantibody levels were higher in hypertensive patients, and this elevation is an independent predictor of HT development.

MeSH terms

  • Autoantibodies / blood*
  • Autoantibodies / metabolism
  • Carbonic Anhydrase I / blood*
  • Carbonic Anhydrase I / metabolism
  • Carbonic Anhydrase II / blood*
  • Carbonic Anhydrase II / metabolism
  • Female
  • Humans
  • Hypertension / blood*
  • Hypertension / diagnosis
  • Male
  • Middle Aged


  • Autoantibodies
  • Carbonic Anhydrase I
  • Carbonic Anhydrase II