Blunted Muscle Mitochondrial Responses to Exercise Training in Older Adults With HIV

J Infect Dis. 2021 Aug 16;224(4):679-683. doi: 10.1093/infdis/jiaa799.


Background: Muscle mitochondrial dysfunction associated with HIV and antiretroviral therapy (ART) may improve with exercise.

Methods: Muscle specimens obtained before and after 24 weeks of exercise in older people with HIV (PWH; n = 18; ART >2 years) and uninfected controls (n = 21) were analyzed for citrate synthase (CS) activity and complexes (C) I-V, manganese superoxide dismutase (MnSOD), peroxisome proliferator-activated receptor-γ coactivator-1 (PGC1α), and voltage-dependent anion channel 1 (VDAC1) content.

Results: Only controls had increased CS, MnSOD, PGC1α, and CIV (P ≤ .01; P < .01 vs PWH) after training.

Conclusions: The blunted mitochondrial adaptations to training in PWH suggests the need for different types of exercise-induced stimulation.

Clinical trials registration: NCT02404792.

Keywords: HIV; aging; exercise; exercise training; mitochondrial function; skeletal muscle.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptation, Physiological
  • Citrate (si)-Synthase / metabolism
  • Exercise*
  • HIV Infections / metabolism*
  • Humans
  • Mitochondria, Muscle / metabolism*
  • Muscle, Skeletal* / metabolism
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism
  • Superoxide Dismutase / metabolism
  • Voltage-Dependent Anion Channel 1 / metabolism


  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • VDAC1 protein, human
  • Superoxide Dismutase
  • Voltage-Dependent Anion Channel 1
  • Citrate (si)-Synthase

Associated data