Natural history of gastric adenomas in patients with familial adenomatosis coli/Gardner's syndrome

Cancer. 1988 Feb 1;61(3):605-11. doi: 10.1002/1097-0142(19880201)61:3<605::aid-cncr2820610331>;2-l.


The natural history of gastric adenomas was studied in 26 patients with familial adenomatosis coli (FAC)/Gardner's syndrome. The patients were followed for an average of 6.8 years (1 year, 5 months to 15 years 4 months) and examined repeatedly using gastric radiography, endoscopy, and biopsy. Gastric adenomas were present in 13 (50%). During the follow-up period, there was a new appearance of gastric adenomas in six patients but no distinct change in number, size, and histologic features in the remaining seven patients. In a 51-year-old man, an antral adenoma that measured 13 mm in diameter and had an irregular central depression did not change in size or morphology during 4 years and 1 month, but malignant change was evident at the time of endoscopic biopsy. The findings indicate that in patients with this disease, gastric adenomas require careful repeated follow-up examinations using endoscopic biopsy and, if feasible, endoscopic removal is recommended.

MeSH terms

  • Adenoma / pathology
  • Adolescent
  • Adult
  • Child
  • Female
  • Follow-Up Studies
  • Gardner Syndrome / genetics
  • Gardner Syndrome / pathology*
  • Gastroscopy
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis / pathology
  • Stomach Neoplasms / pathology